Add article(s) associated with A-beta protein precursor family

The chick embryo appears as a natural model for research in beta- amyloid precursor protein processing.
Carrodeguas J.A., Rodolosse A., Garza M.V. et al
2005, Neuroscience (134) 1285-1300
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K., Goethals M., Martens L. et al
2003, Nat. Biotechnol. (21) 566-569
Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.
Tang K., Wang C., Shen C. et al
2003, Eur. J. Neurosci. (18) 102-108
A cell biological perspective on Alzheimer's disease.
Annaert W., De, Strooper B. et al
2002, Annu. Rev. Cell Dev. Biol. (18) 25-51
The galvanization of beta-amyloid in Alzheimer's disease.
Bush A.I., Tanzi R.E.
2002, Proc. Natl. Acad. Sci. U.S.A. (99) 7317-7319
Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.
Rank K.B., Pauley A.M., Bhattacharya K. et al
2002, FEBS Lett. (514) 263-268
The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.
Roncarati R., Sestan N., Scheinfeld M.H. et al
2002, Proc. Natl. Acad. Sci. U.S.A. (99) 7102-7107
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
Scheinfeld M.H., Roncarati R., Vito P. et al
2002, J. Biol. Chem. (277) 3767-3775
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg R.L., Feingold E.A., Grouse L.H. et al
2002, Proc. Natl. Acad. Sci. U.S.A. (99) 16899-16903
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Tarr P.E., Roncarati R., Pelicci G. et al
2002, J. Biol. Chem. (277) 16798-16804
Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.
Taru H., Iijima K.-I., Hase M. et al
2002, J. Biol. Chem. (277) 20070-20078
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
The, FANTOM Consortium, the et al
2002, Nature (420) 563-573
Octylphenol (OP) alters the expression of members of the amyloid protein family in the hypothalamus of the snapping turtle, Chelydra serpentina serpentina.
Trudeau V.L., Chiu S., Kennedy S.W. et al
2002, Environ. Health Perspect. (110) 269-275
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
Weidemann A., Eggert S., Reinhard F.B.M. et al
2002, Biochemistry (41) 2825-2835
Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
White A.R., Multhaup G., Galatis D. et al
2002, J. Neurosci. (22) 365-376
Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.
Ando K., Iijima K.-I., Elliott J.I. et al
2001, J. Biol. Chem. (276) 40353-40361
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
Cupers P., Orlans I., Craessaerts K. et al
2001, J. Neurochem. (78) 1168-1178
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered structure containing superoxide dismutase-like subunits.
Curtain C.C., Ali F., Volitakis I. et al
2001, J. Biol. Chem. (276) 20466-20473
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.
Grabowski T.J., Cho H.S., Vonsattel J.P.G. et al
2001, Ann. Neurol. (49) 697-705
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch.
Gu Y., Misonou H., Sato T. et al
2001, J. Biol. Chem. (276) 35235-35238
Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module.
Kajkowski E.M., Lo C.F., Ning X. et al
2001, J. Biol. Chem. (276) 18748-18756
Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta- peptide 1-42-associated oxidative stress and neurotoxicity.
Kanski J., Varadarajan S., Aksenova M. et al
2001, Biochim. Biophys. Acta (1586) 190-198
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
Kimberly W.T., Zheng J.B., Guenette S.Y. et al
2001, J. Biol. Chem. (276) 40288-40292
Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.
Kontush A.
2001, Cell. Mol. Neurobiol. (21) 299-315
Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).
Kumar V.B., Vyas K., Franko M. et al
2001, Biochem. Cell Biol. (79) 57-67
C-jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.
Matsuda S., Yasukawa T., Homma Y. et al
2001, J. Neurosci. (21) 6597-6607
Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development.
Musa A., Lehrach H., Russo V.E.A. et al
2001, Dev. Genes Evol. (211) 563-567
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
Nilsberth C., Westlind-Danielsson A., Eckman C.B. et al
2001, Nat. Neurosci. (4) 887-893
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.
Ohsawa I., Takamura C., Kohsaka S. et al
2001, J. Neurochem. (76) 1411-1420
A novel gamma -secretase assay based on detection of the putative C- terminal fragment-gamma of amyloid beta protein precursor.
Pinnix I., Musunuru U., Tun H. et al
2001, J. Biol. Chem. (276) 481-487
Functional annotation of a full-length mouse cDNA collection.
RIKEN, FANTOM Consortium
2001, Nature (409) 685-690
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
Scheuermann S., Hambsch B., Hesse L. et al
2001, J. Biol. Chem. (276) 33923-33929
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).
Standen C.L., Brownlees J., Grierson A.J. et al
2001, J. Neurochem. (76) 316-320
Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region.
Tsuchida K., Shioi J., Yamada S. et al
2001, J. Biol. Chem. (276) 37155-37160
Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis.
Van, den, Hurk W.H. et al
2001, Brain Res. Mol. Brain Res. (97) 13-20
Beta amyloid peptide (Abeta42) is internalized via the G-protein- coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.
Yazawa H., Yu Z.-X., Takeda K. et al
2001, FASEB J. (15) 2454-2462
Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein.
Beck M., Brueckner M.K., Holzer M. et al
2000, Neuroscience (95) 243-254
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P., Shibata Y., Hayatsu N. et al
2000, Genome Res. (10) 1617-1630
What the evolution of the amyloid protein precursor supergene family tells us about its function.
Coulson E.J., Paliga K., Beyreuther K. et al
2000, Neurochem. Int.
High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.
Finckh U., Mueller-Thomsen T., Mann U. et al
2000, Am. J. Hum. Genet. (66) 110-117
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.
Iijima K.-I., Ando K., Takeda S. et al
2000, J. Neurochem. (75) 1085-1091
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
Kamal A., Stokin G.B., Yang Z. et al
2000, Neuron (28) 449-459
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Kumar-Singh S., De, Jonghe C. et al
2000, Hum. Mol. Genet. (9) 2589-2598
Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis.
Kwok J.B.J., Li Q.X., Hallupp M. et al
2000, Ann. Neurol. (47) 249-253
A second cytotoxic proteolytic peptide derived from amyloid beta- protein precursor.
Lu D.C., Rabizadeh S., Chandra S. et al
2000, Nat. Med. (6) 397-404
Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
Miravalle L., Tokuda T., Chiarle R. et al
2000, J. Biol. Chem. (275) 27110-27116
Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.
Murrell J.R., Hake A.M., Quaid K.A. et al
2000, Arch. Neurol. (57) 885-887
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.
Passer B., Pellegrini L., Russo C. et al
2000, J. Alzheimers Dis. (2) 289-301
Solution structures in aqueous SDS micelles of two amyloid beta peptides of Abeta(1-28) mutated at the alpha-secretase cleavage site.
Poulsen S.-A., Watson A.A., Craik D.J. et al
2000, J. Struct. Biol. (130) 142-152
RIKEN integrated sequence analysis (RISA) system-384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K., Itoh M., Aizawa K. et al
2000, Genome Res. (10) 1757-1771
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.
Tokuda T., Calero M., Matsubara E. et al
2000, Biochem. J. (348) 359-365
Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.
Walter J., Schindzielorz A., Hartung B. et al
2000, J. Biol. Chem. (275) 23523-23539
Beta-amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Wang H.-Y., Lee D.H.S., D&apos et al
2000, J. Biol. Chem. (275) 5626-5632
The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
Zhang S., Iwata K., Lachenmann M.J. et al
2000, J. Struct. Biol. (130) 130-141
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.
Ancolio K., Dumanchin C., Barelli H. et al
1999, Proc. Natl. Acad. Sci. U.S.A. (96) 4119-4124
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.
Ando K., Oishi M., Takeda S. et al
1999, J. Neurosci. (19) 4421-4427
The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction.
Brouillet E., Trembleau A., Galanaud D. et al
1999, J. Neurosci. (19) 1717-1727
High-efficiency full-length cDNA cloning.
Carninci P., Hayashizaki Y.
1999, Meth. Enzymol. (303) 19-44
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Gervais F.G., Xu D., Robertson G.S. et al
1999, Cell (97) 395-406
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Huang X., Atwood C.S., Hartshorn M.A. et al
1999, Biochemistry (38) 7609-7616
Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase.
Isohara T., Horiuchi A., Watanabe T. et al
1999, Biochem. Biophys. Res. Commun. (258) 300-305
Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.
Liu S.T., Howlett G., Barrow C.J. et al
1999, Biochemistry (38) 9373-9378
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
Perez R.G., Soriano S., Hayes J.D. et al
1999, J. Biol. Chem. (274) 18851-18856
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Rossjohn J., Cappai R., Feil S.C. et al
1999, Nat. Struct. Biol. (6) 327-331
Cysteine 144 is a key residue in the copper reduction by the beta- amyloid precursor protein.
Ruiz F.H., Gonzalez M., Bodini M. et al
1999, J. Neurochem. (73) 1288-1292
Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
Tomita S., Ozaki T., Taru H. et al
1999, J. Biol. Chem. (274) 2243-2254
Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.
Varadarajan S., Yatin S., Kanski J. et al
1999, Brain Res. Bull. (50) 133-141
A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein.
Watanabe T., Sukegawa J., Tomita S. et al
1999, J. Neurochem. (72) 549-556
Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.
Barnes N.Y., Li L., Yoshikawa K. et al
1998, J. Neurosci. (18) 5869-5880
Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
Coles M., Bicknell W., Watson A.A. et al
1998, Biochemistry (37) 11064-11077
Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.
Cras P., van, Harskamp F. et al
1998, Acta Neuropathol. (96) 253-260
cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray.
Iijima K., Lee D.-S., Okutsu J. et al
1998, Biochem. J. (330) 29-33
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
Multhaup G., Ruppert T., Schlicksupp A. et al
1998, Biochemistry (37) 7224-7230
Analysis of pufferfish homologues of the AT-rich human APP gene.
Villard L., Tassone F., Crnogorac-Jurcevic T. et al
1998, Gene (210) 17-24
PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.
Zheng P., Eastman J., Vande et al
1998, Proc. Natl. Acad. Sci. U.S.A. (95) 14745-14750
Amyloid precursor protein in Guinea pigs - complete cDNA sequence and alternative splicing.
Beck M., Mueller D., Bigl V. et al
1997, Biochim. Biophys. Acta (1351) 17-21
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Eckman C.B., Mehta N.D., Crook R. et al
1997, Hum. Mol. Genet. (6) 2087-2089
A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.
Hattori M., Tsukahara F., Furuhata Y. et al
1997, Nucleic Acids Res. (25) 1802-1808
Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Martel C.L., Mackic J.B., Matsubara E. et al
1997, J. Neurochem. (69) 1995-2004
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.
Mok S.S., Sberna G., Heffernan D. et al
1997, FEBS Lett. (415) 303-307
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
Oishi M., Nairn A.C., Czernik A.J. et al
1997, Mol. Med. (3) 111-123
Expression of the APP gene family in brain cells, brain development and aging.
Sandbrink R., Monning U., Masters C.L. et al
1997, Gerontology (43) 119-131
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Scheidig A.J., Hynes T.R., Pelletier L.A. et al
1997, Protein Sci. (6) 1806-1824
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
Walter J., Capell A., Hung A.Y. et al
1997, J. Biol. Chem. (272) 1896-1903
Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.
Walter M.F., Mason P.E., Mason R.P. et al
1997, Biochem. Biophys. Res. Commun. (233) 760-764
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Yan S.D., Fu J., Soto C. et al
1997, Nature (389) 689-695
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
Beher D., Hesse L., Masters C.L. et al
1996, J. Biol. Chem. (271) 1613-1620
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Borg J.-P., Ooi J., Levy E. et al
1996, Mol. Cell. Biol. (16) 6229-6241
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.
Chow N., Korenberg J.R., Chen X.-N. et al
1996, J. Biol. Chem. (271) 11339-11346
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Guenette S.Y., Chen J., Jondro P.D. et al
1996, Proc. Natl. Acad. Sci. U.S.A. (93) 10832-10837
Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment.
Kohno T., Kobayashi K., Maeda T. et al
1996, Biochemistry (35) 16094-16104
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Maruyama K., Tomita T., Shinozaki K. et al
1996, Biochem. Biophys. Res. Commun. (227) 730-735
APP gene family. Alternative splicing generates functionally related isoforms.
Sandbrink R., Masters C.L., Beyreuther K. et al
1996, Ann. N. Y. Acad. Sci. (777) 281-287
A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease.
Brooks W.S., Martins R.N., De et al
1995, Neurosci. Lett. (199) 183-186
Beta-amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy.
Levy E., Amorim A., Frangione B. et al
1995, Neurobiol. Aging (16) 805-808
The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.
Pangalos M.N., Efthimiopoulos S., Shioi J. et al
1995, J. Biol. Chem. (270) 10388-10391
The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.
Shioi J., Pangalos M.N., Ripellino J.A. et al
1995, J. Biol. Chem. (270) 11839-11844
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.
Sticht H., Bayer P., Willbold D. et al
1995, Eur. J. Biochem. (233) 293-298
Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.
Farlow M., Murrell J., Ghetti B. et al
1994, Neurology (44) 105-111
The beta A4 amyloid precursor protein binding to copper.
Hesse L., Beher D., Masters C.L. et al
1994, FEBS Lett. (349) 109-116
Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.
Peacock M.L., Murman D.L., Sima A.A.F. et al
1994, Ann. Neurol. (35) 432-438
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.
Small D.H., Nurcombe V., Reed G. et al
1994, J. Neurosci. (14) 2117-2127
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.
Suzuki T., Oishi M., Marshak D.R. et al
1994, EMBO J. (13) 1114-1122
Solution structure of residues 1-28 of the amyloid beta-peptide.
Talafous J., Marcinowski K.J., Klopman G. et al
1994, Biochemistry (33) 7788-7796
The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.
Wisniewski T., Lalowski M., Levy E. et al
1994, Ann. Neurol. (35) 245-246
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
Bush A.I., Multhaup G., Moir R.D. et al
1993, J. Biol. Chem. (268) 16109-16112
A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.
Denman R.B., Rosenzcwaig R., Miller D.L. et al
1993, Biochem. Biophys. Res. Commun. (192) 96-103
Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations.
Liepnieks J.J., Ghetti B., Farlow M. et al
1993, Biochem. Biophys. Res. Commun. (197) 386-392
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o).
Nishimoto I., Okamoto T., Matsuura Y. et al
1993, Nature (362) 75-79
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.
Roher A.E., Lowenson J.D., Clarke S. et al
1993, Proc. Natl. Acad. Sci. U.S.A. (90) 10836-10840
Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry.
Sola C., Mengod G., Ghetti B. et al
1993, Brain Res. Mol. Brain Res. (17) 340-346
Characterization of beta-amyloid peptide from human cerebrospinal fluid.
Vigo-Pelfrey C., Lee D., Keim P. et al
1993, J. Neurochem. (61) 1965-1968
More missense in amyloid gene.
Carter D.A., Desmarais E., Bellis M. et al
1992, Nat. Genet. (2) 255-256
Framing beta-amyloid.
Hardy J.
1992, Nat. Genet. (1) 233-234
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
Hendriks L., van, Duijn C.M. et al
1992, Nat. Genet. (1) 218-221
Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse.
Izumi R., Yamada T., Yoshikai S.I. et al
1992, Gene (112) 189-195
Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.
Jones C.T., Morris S., Yates C.M. et al
1992, Nat. Genet. (1) 306-309
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.
Kamino K., Orr H.T., Payami H. et al
1992, Am. J. Hum. Genet. (51) 998-1014
Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.
Koenig G., Moenning U., Czech C. et al
1992, J. Biol. Chem. (267) 10804-10809
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
Mullan M., Crawford F., Axelman K. et al
1992, Nat. Genet. (1) 345-347
A Xenopus homologue of the human beta-amyloid precursor protein: developmental regulation of its gene expression.
Okado H., Okamoto H.
1992, Biochem. Biophys. Res. Commun. (189) 1561-1568
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Chartier-Harlin M.-C., Crawford F., Houlden H. et al
1991, Nature (353) 844-846
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
Goate A., Chartier-Harlin M.-C., Mullan M. et al
1991, Nature (349) 704-706
Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein.
Heald S.L., Tilton R.F., Jr. et al
1991, Biochemistry (30) 10467-10478
Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis.
Johnstone E.M., Chaney M.O., Norris F.H. et al
1991, Brain Res. Mol. Brain Res. (10) 299-305
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
Murrell J.R., Farlow M., Ghetti B. et al
1991, Science (254) 97-99
Mis-sense mutation Val->Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
Naruse S., Igarashi S., Kobayashi H. et al
1991, Lancet (337) 978-979
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
Podlisny M.B., Tolan D.R., Selkoe D.J. et al
1991, Am. J. Pathol. (138) 1423-1435
Purification and tissue level of the beta-amyloid peptide precursor of rat brain.
Potempska A., Styles J., Mehta P. et al
1991, J. Biol. Chem. (266) 8464-8469
The 717Val-->Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
Yoshioka K., Miki T., Katsuya T. et al
1991, Biochem. Biophys. Res. Commun. (178) 1141-1146
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.
de, Strooper B., van et al
1991, Biochim. Biophys. Acta (1129) 141-143
X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Hynes T.R., Randal M., Kennedy L.A. et al
1990, Biochemistry (29) 10018-10022
Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.
Kido H., Fukutomi A., Schilling J. et al
1990, Biochem. Biophys. Res. Commun. (167) 716-721
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
Levy E., Carman M.D., Fernandez-Madrid I.J. et al
1990, Science (248) 1124-1126
Genomic organization of the human amyloid beta-protein precursor gene.
Yoshikai S.-I., Sasaki H., Doh-ura K. et al
1990, Gene (87) 257-263
Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus.
Fukuchi K., Martin G.M., Deeb S.S. et al
1989, Nucleic Acids Res. (17) 5396-5396
Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.
Johnstone E.M., Chaney M.O., Moore R.E. et al
1989, Biochem. Biophys. Res. Commun. (163) 1248-1255
The sequence of the two extra exons in rat preA4.
Kang J., Mueller-Hill B.
1989, Nucleic Acids Res. (17) 2130-2130
Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.
La, Fauci G., Lahiri D.K. et al
1989, Biochem. Biophys. Res. Commun. (159) 297-304
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.
Lemaire H.-G., Salbaum J.M., Multhaup G. et al
1989, Nucleic Acids Res. (17) 517-522
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
Oltersdorf T., Fritz L.C., Schenk D.B. et al
1989, Nature (341) 144-147
Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor.
Yamada T., Sasaki H., Dohura K. et al
1989, Biochem. Biophys. Res. Commun. (158) 906-912
A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.
de, Sauvage F., Octave J.N. et al
1989, Science (245) 651-653
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.
Dyrks T., Weidemann A., Multhaup G. et al
1988, EMBO J. (7) 949-957
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.
Kitaguchi N., Takahashi Y., Tokushima Y. et al
1988, Nature (331) 530-532
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
Ponte P., Gonzalez-Dewhitt P., Schilling J. et al
1988, Nature (331) 525-527
A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.
Schon E.A., Mita S., Sadlock J. et al
1988, Nucleic Acids Res. (16) 9351-9351
Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
Schubert D., Schroeder R., LaCorbiere M. et al
1988, Science (241) 223-226
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
Shivers B.D., Hilbich C., Multhaup G. et al
1988, EMBO J. (7) 1365-1370
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
Tanzi R.E., McClatchey A.I., Lamperti E.D. et al
1988, Nature (331) 528-530
Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.
Zain S.B., Salim M., Chou W.G. et al
1988, Proc. Natl. Acad. Sci. U.S.A. (85) 929-933
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.
Goldgaber D., Lerman M.I., McBride O.W. et al
1987, Science (235) 877-880
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Kang J., Lemaire H.-G., Unterbeck A. et al
1987, Nature (325) 733-736
Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.
Pardridge W.M., Vinters H.V., Yang J. et al
1987, J. Neurochem. (49) 1394-1401
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.
Robakis N.K., Ramakrishna N., Wolfe G. et al
1987, Proc. Natl. Acad. Sci. U.S.A. (84) 4190-4194
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
Tanzi R.E., Gusella J.F., Watkins P.C. et al
1987, Science (235) 880-884
Complementary DNA for the mouse homolog of the human amyloid beta protein precursor.
Yamada T., Sasaki H., Furuya H. et al
1987, Biochem. Biophys. Res. Commun. (149) 665-671
Purification of protease nexin II from human fibroblasts.
van, Nostrand W.E., Cunningham D.D. et al
1987, J. Biol. Chem. (262) 8508-8514
Relationship between canine dementia and Alzheimer's disease.
Gallego C., Sanchez-Diaz R., Sarasa L. et al
Submitted FEB-2005 to the EMBL GenBank DDBJ databases
Amyloid precursor protein 770.
Kimura A., Takahashi T.
Submitted SEP-1999 to the EMBL GenBank DDBJ databases
Isolation and characterization of cDNA for macaque neurological disease genes.
Kusuda J., Osada N., Tanuma R. et al
Submitted OCT-2003 to the EMBL GenBank DDBJ databases
Isolation and characterization of cDNA for macaque neurological disease genes.
Kusuda J., Osada N., Tanuma R. et al
Submitted OCT-2003 to the EMBL GenBank DDBJ databases
NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
Livingston R.J., Rieder M.J., Rajkumar N. et al
Submitted FEB-2005 to the EMBL GenBank DDBJ databases
NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
Livingston R.J., Rieder M.J., Rajkumar N. et al
Submitted FEB-2005 to the EMBL GenBank DDBJ databases
Evaluation and characterization of a porcine small intestine cDNA library.
Winteroe A.K., Fredholm M.
Submitted JAN-1997 to the EMBL GenBank DDBJ databases
Evaluation and characterization of a porcine small intestine cDNA library.
Winteroe A.K., Fredholm M.
Submitted JAN-1997 to the EMBL GenBank DDBJ databases
Introduction of six mutations into the mouse genome using 'Hit and Run' gene-targeting: introduction of familial Alzheimer's disease mutations into the mouse amyloid precursor protein gene and humanization of the A-beta fragment.
Wragg M.A., Busfield F., Duff K. et al
Submitted DEC-1996 to the EMBL GenBank DDBJ databases
Introduction of six mutations into the mouse genome using 'Hit and Run' gene-targeting: introduction of familial Alzheimer's disease mutations into the mouse amyloid precursor protein gene and humanization of the A-beta fragment.
Wragg M.A., Busfield F., Duff K. et al
Submitted DEC-1996 to the EMBL GenBank DDBJ databases